Recombinant Human BCAM/Basal Cell Adhesion Molecule,BR

产品属性 Product Attributes

基本信息

别名： Basal cell adhesion molecule;Auberger B antigen;B-CAM cell surface glycoprotein;F8/G253 antigen;Lutheran antigen;Lutheran blood group glycoprotein;CD239;BCAM;LU;MSK19
中文名称: Recombinant Human BCAM/Basal Cell Adhesion Molecule
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： Basal cell adhesion molecule (BCAM，CD239) is an immunoglobulin superfamily protein that arises from alternate splicing of the Lutheran blood group molecule (Lu).The ECD of human BCAM contains two Ig-like V-type domains and three Ig-like C2-type domains.It shares 73% aa sequence identity with the ECDs of mouse and rat BCAM.BCAM is widely expressed in epithelial and endothelial tissues including in the vasculature，kidney glomerulus，small intestine，colon，hair follicle outer root sheath，and basal keratinocytes of the skin during inflammation.BCAM is also expressed on vascular and visceral smooth muscle cells and at the neuromuscular junction of skeletal muscle.BCAM is upregulated on carcinomas，particularly ovarian，sarcomas，astrocytomas，and melanomas.It may mediate intracellular signaling.It cooperates with Integrins β1 and αVβ3 as an adhesion receptor for Laminins which contain the α5 chain.The Lutheran isoform is aberrantly phosphorylated in erythroid disorders and can enhance Lamininmediated adhesion of erythrocytes to vascular endothelial cells.
来源： Human Cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

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