Recombinant Mouse BAFFR/TNFRSF13C,BR

产品属性 Product Attributes

基本信息

别名： BAFF R;BAFFR;BR3;CD268;TNFRSF13C
中文名称: Recombinant Mouse BAFFR/TNFRSF13C
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： Tumor necrosis factor receptor superfamily，member 13C (TNFRSF13C) also known as B-cell-activating factor receptor (BAFFR) and CD268 antigen，is a member of the tumor necrosis factor receptor superfamily.BAFF promotes the survival of B cells and is essential for B cell maturation.BAFF binds to three TNF receptor superfamily members: B-cell maturation antigen (BCMA/TNFRSF17)，transmembrane activator and calcium-modulator and cyclophilin ligand interactor (TACI/TNFRSF13B) and BAFF receptor (BAFFR/BR3/TNFRSF13C).These receptors are type III transmembrane proteins that lack a signal peptide.BAFF R is highly expressed in spleen，lymph node and resting B cells.It is also expressed at lower levels in activated B cell，in resting CD4+ T cells，in thymus and peripheral blood leukocytes.BAFF knockout mice lack mature B cells.Similarly，A/WySnJ mice that are defective in BAFF-R intracellular signaling also lack mature B cells，suggesting that BAFF R is the critical receptor for BAFF during B lymphopoiesis.It has been proposed that abnormally high levels of BAFFR/TNFRSF13C (CD268) may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells.
来源： Human Cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

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