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- Recombinant Human CTLA-4/CD152/Cytotoxic T-Lymphocyte Protein 4,BR
Recombinant Human CTLA-4/CD152/Cytotoxic T-Lymphocyte Protein 4,BR
Recombinant Human CTLA-4/CD152/Cytotoxic T-Lymphocyte Protein 4
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产品属性 Product Attributes
基本信息
别名: Cytotoxic T-lymphocyte protein 4;Cytotoxic T-lymphocyte-associated antigen 4;CTLA4;CD152中文名称: Recombinant Human CTLA-4/CD152/Cytotoxic T-Lymphocyte Protein 4
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状): Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
产品信息
背景说明: Cytotoxic Tlymphocyte 4(CTLA-4,CD152),is a type I transmembrane T cell inhibitory molecule that is a member of the Ig superfamily.Human or mouse CTLA4 cDNA encodes 223 amino acids (aa) including a 35 aa signal sequence,a 126 aa extracellular domain (ECD) with one Ig-like V-type domain,a 21 aa transmembrane (TM) sequence,and a 41 aa cytoplasmic sequence.It is widely expressed with highest levels in lymphoid tissues.CD28 and CTLA-4,together with their ligands,B7-1 and B7-2,constitute one of the dominant costimulatory pathways that regulate T and B cell responses.CD28 and CTLA-4 are structurally homologous molecules that are members of the immunoglobulin (Ig) gene superfamily.CTLA4 transmits an inhibitory signal to T cells,whereas CD28 transmits a stimulatory signal.Intracellular CTLA4 is also found in regulatory T Cells and may play an important role in their functions.Tcell activation through the Tcell receptor and CD28 leads to increased expression of CTLA4.来源: Human Cells
其它标识
溶剂: Dissolve the lyophilized protein in distilled water.内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.
产品介绍 Product Introduction
暂无数据注意事项 Considerations
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗,食品及化妆品等用途。请勿存放于普通住宅区。2.为了您的安全和健康,请穿好实验服并佩戴一次性手套和口罩操作。
3.实验结果可由多种因素影响,相关处理只限于产品本身,不涉及其他赔偿。