Recombinant Human ESAM,BR

产品属性 Product Attributes

基本信息

别名： Endothelial Cell-Selective Adhesion Molecule;ESAM
中文名称: Recombinant Human ESAM
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： Endothelial Cell Adhesion Molecule (ESAM) is a 55 kDa type I transmembrane glycoprotein member of the JAM family of immunoglobulin superfamily molecules.The 390 amino acid Human ESAM contains a 216 amino acid extracellular domain (ECD) with a V-type and a C2-type immunoglobulin (Ig) domain.ESAM is specifically expressed at endothelial tight junctions and on activated platelets and performs homophilic adhesion activity.The adaptor protein membrane-associated guanylate kinase MAGI-1 has been identified as an intracellular binding partner of ESAM.In addition，ESAM at endothelial tight junctions participates in the migration of neutrophils through the vessel wall，possibly by influencing endothelial cell contacts.ESAM-deficient mice were described with lowered angiogenic potential，and accordingly，overexpression of ESAM is closely associated with certain tumor growth and metastasis.ESAM is expressed on endothelial cells，activated platelets and megakaryocytes.The ECD of human and mouse ESAM share 69% amino acid identity.
来源： Human Cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 IEU/ug)as determined by LAL test.

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