Recombinant Human VSIG4,BR

产品属性 Product Attributes

基本信息

别名： V-Set and Immunoglobulin Domain-Containing Protein 4;Protein Z39Ig;VSIG4;CRIg;Z39IG
中文名称: Recombinant Human VSIG4
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： V-Set and Immunoglobulin Domain-Containing Protein 4 (VSIG4) is a 45-50 kDa macrophage-specific transmembrane glycoprotein that belongs to the B7 family-related protein and an Ig superfamily member.In contrast to the B7 family members which contain two IgG domains，VSIG4 contains one complete V-type Ig domain and a truncated C-type I g domain.VSIG4 is abundantly expressed in several fetal tissues.In adult tissues，the highest expression of VSIG4 is in lung and placenta.It is also expressed in resting macrophages.No VSIG4 expression appears to be present in T and B cells.The specific expression of VSIG4 on resting macrophages in tissue suggests that this inhibitory ligand may be important for the maintenance of T cell unresponsiveness in healthy tissues.VSIG4 functions as a negative regulator of T cell activation，and may be involved in the maintenance of peripheral T cell tolerance，and is also identified as a potent suppressor of established inflammation.VSIG4 is a phagocytic receptor，strong negative regulator of T-cell proliferation and IL2 production.It is a potent inhibitor of the alternative complement pathway convertases.Human VSIG4 is 399 amino acids (aa) in length.It is a type I transmembrane (TM) glycoprotein that contains a 264 aa extracellular domain (ECD) (aa 20 - 283) and a 95 aa cytoplasmic region.
来源： Human Cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

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