Recombinant Human Siglec-10,BR

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基本信息

别名： SIGLEC10;MGC126774;PRO940;Siglec10;SLG2;sialic acid-binding Ig-like lectin 10;Siglec-10;siglec-like gene 2;Siglec-like protein 2;SLG2sialic acid binding Ig-like lectin 10 Ig-like lectin 7
中文名称: Recombinant Human Siglec-10
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： Siglecs (sialic acid binding Ig-like lectins) are I-type lectins that belong to the immunoglobulin superfamily.They are characterized by an N-terminal Ig-like V-type domain which mediates sialic acid binding，followed by a varying number of Ig-like C2-type domains.Siglecs 5-11 constitute the CD33/Siglec-3 related group，and are differentially expressed in the hematopoietic system.Siglec-G is the apparent ortholog of human Siglec-10.We describe here a novel member of the siglec protein family that shares a similar structure including five Ig-like domains，a transmembrane domain，and a cytoplasmic tail containing two ITIM-signaling motifs.Siglec-10 was identified through database mining of an asthmatic eosinophil EST library.Siglec-10 binds sialated proteins and lipids in alpha 2，3 or alpha 2，6 linkage and shows a preference for GT1b gangliosides.This binding can be modulated by cis interactions of Siglec-10 with sialated molecules expressed on the same cell.When tyrosine phosphorylated，the cytoplasmic ITIMs interact with phosphatases SHP-1 and SHP-2 to propagate inhibitory signals.The Siglec-10-VAP-1 interaction seems to mediate lymphocyte adhesion to endothelium and has the potential to modify the inflammatory microenvironment via the enzymatic end products.
来源： Human Cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

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