Recombinant Mouse Leucine-rich Repeats and IG-like Domains Protein 1/LRIG1,BR

产品属性 Product Attributes

基本信息

别名： Leucine-rich repeats and immunoglobulin-like domains protein 1;LIG-1;Lrig1
中文名称: Recombinant Mouse Leucine-rich Repeats and IG-like Domains Protein 1/LRIG1
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： LRIG1 is a leucine-rich repeat (LRR) and Ig-like domain-containing single-pass transmembrane glycoprotein.LRIG1 shares 45-50% aa identity with its mammalian paralogs，LRIG2 and LRIG3.LIRG1 is expressed widely throughout mouse and human tissues，including the liver，brain，stomach，small intestine，skeletal muscle，cornea，and hair follicle.It has been shown to suppress tumor growth，regulate tissue homeostasis，and maintain stem cell quiescence.The LRIG1 ECD contains three C-type Ig-like domains as well as fifteen LRRs that are flanked by cysteine-rich regions.LRIG1 functions as a tumor suppressor by controlling cell proliferation through the negative regulation of the EGF family of receptor tyrosine kinases.LRIG1 expression，which is often dysregulated in human cancers，is a prognostic indicator of cancer development and relapse.Decreased LRIG1 is associated with an increase in recurrence and mortality for a variety of cancers including breast，uterine，headandneck，glioma，prostate，and squamous cell.Tissue homeostasis and stem cell dormancy is also thought to be modulated by the actions of LRIG1 on cell proliferation.
来源： Human Cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

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注意事项 Considerations

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