Recombinant Mouse Angiopoietin-like Protein 3/ANGPTL3,BR

产品属性 Product Attributes

基本信息

别名： Angiopoietin-related Protein 3;Angiopoietin-like protein 3;Angptl3
中文名称: Recombinant Mouse Angiopoietin-like Protein 3/ANGPTL3
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： Angiopoietin-likeProtein 3 (ANGPTL3) is a secreted glycoprotein that is structurally related to the angiopoietins.Mature mouse ANGPTL3 contains an N-terminalcoiled coil domain and a C-terminalfibrinogen-likedomain.Within the Nterminalfragment，mouse ANGPTL3 shares 83% and 92% aa sequence identity with human and rat ANGPTL3，respectively.ANGPTL3 is expressed in the liver from early in development through adulthood.ANGPTL3 directly inhibits lipoprotein lipase (LPL) and endothelial lipase (EL)，enzymesresponsible for hydrolyzing circulating triglycerides and HDL phospholipids.This activity requires a putative heparin-bindingmotif which is N-terminalto thecoiled coil domain.Proteolytic removal of the fibrinogen-likedomain from the N-terminalfragment serves to activate ANGPTL3 and increase its ability toinhibit LPL in vitro and function in vivo.ANGPTL3 promotes an increase in circulating triglyceride levels without altering VLDL or HDL secretion oruptake.ANGPTL3 expression in vivo is up-regulatedby LXR agonists anddown-regulatedby insulin，leptin，and agonists of TRβ or PPARβ.ANGPTL3，secreted by fetal liver cells，also promotes the expansion of hematopoietic stem cells.
来源： Human Cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

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