Recombinant Human PIGR/Polymeric immunoglobulin receptor,BR

产品属性 Product Attributes

基本信息

别名： Polymeric Immunoglobulin Receptor;PIgR;Poly-Ig Receptor;Hepatocellular Carcinoma-Associated Protein TB6;PIGR
中文名称: Recombinant Human PIGR/Polymeric immunoglobulin receptor
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： The human Polymeric Immunoglobulin Receptor (pIgR) is a 100 kDa type I transmembrane glycoprotein.Its precursor is 764 amino acids.It contains an 18 amino acid signal sequence，a 620 amino acid extracellular region，a 23 amino acid transmembrane fragment，and a 103 amino acid cytoplasmic domain.pIgR is synthesized by secretory epithelial cells with five Ig-like domains in extracellular region，and transfer to the basolateral plasma membrane.For IgA and IgM polymers，in addition to α-heavy chains and light Ig chains，a short polypeptide named joining chain (J chain) is also contained and required.pIgR can bind larger polymers of IgA (pIgA) and pentameric IgM as a carrier that transports IgA and IgM across epithelium.The receptor-ligand complexes are endocytosed and transcytosed to the apical surface，then proteolytic cleavage of the sixth extracellular domain of pIgR and generate secretory IgA (SIgA)，the pIgR fragment is referred to as secretory component (SC).SIgA is a important component of the mucosal immune system.SC is anti-microbial properties and protects SIgA from proteolytic degradation
来源： Human Cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/μg(1 EU/μg)as determined by LAL test.

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