Recombinant Human Azurocidin/CAP37/HBP,BR

产品属性 Product Attributes

基本信息

别名： Azurocidin;Cationic Antimicrobial Protein CAP37;Heparin-Binding Protein;HBP;AZU1
中文名称: Recombinant Human Azurocidin/CAP37/HBP
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of 20mM HEPES, 150mM NaCl, pH 7.5.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： Azurocidin is an Azurophil granule antibiotic protein，with monocyte chemotactic and antibacterial activity.The Azurophil granules，specialized lysosomes of the neutrophil，contain at least 10 proteins implicated in the killing of microorganisms.Azurocidin is a member of the serine protease family that includes Cathepsin G，Neutrophil Elastase (NE)，and Proteinase 3 (PR3)，however，Azurocidin is not a serine proteinase since the active site serine and histidine residues are replaced.Human Azurocidin together with NE and PR3 are expressed coordinately and are packaged together into azurophil granules during neutrophil differentiation.Azurocidin has been identified as a modulator of endothelial permeability and an important multifunctional inflammatory mediator.Neutrophils arriving first at sites of inflammation release Azurocidin which acts in a paracrine fashion on endothelial cells causing the development of intercellular gaps and allowing leukocyte extravasation.Azurocidin thus be regarded as a reasonable therapeutic target for a variety of inflammatory disease conditions.
来源： Human Cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

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