Recombinant Human Nectin-1/PVRL1,BR

产品属性 Product Attributes

基本信息

别名： Poliovirus Receptor-Related Protein 1;Herpes Virus Entry Mediator C;Herpesvirus Entry Mediator C;HveC;Herpesvirus Ig-Like Receptor;HIgR;Nectin-1;CD111;PVRL1;HVEC;PRR1
中文名称: Recombinant Human Nectin-1/PVRL1
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： Nectin-1 is a type I transmembrane glycoprotein belonging to the Ig superfamily.Nectin-1 promotes cell-cell contacts by forming homophilic or heterophilic trans-dimers.Heterophilic interactions have been detected between Nectin-1 and Nectin-3 and between Nectin-1 and Nectin-4.Nectin ECDs contain three Ig like domains: an N terminal V type that mediates ligand binding，and two C2 type.Nectin-1 binds viral Glycoprotein D to mediate Herpesvirus (but not Poxvirus) entry into vaginal mucosa，sensory neurons and fibroblasts.In forming adherens junctions and synapses，Nectin-1 and Nectin-3 initiate cell-cell interactions，recruiting αvβ3 integrin extracellularly and cadherins intracellularly through afadin and other junctional proteins.These interactions organize the cytoskeleton，strengthen attachment to basement membrane and promote further cell-cell connections.Nectin-1 and Nectin-3 have been found to localize assymetrically along the chemical synapse，with Nectin-1 primarily on the axonal side and Nectin-3 on the dendritic side.Deficiency of Nectin-1 can result in cleft lip/palate ectodermal dysplasia.Nectin-1 downregulation in epithelial cancers is mediated in part by ectodomain shedding，but it may contribute to invasiveness.
来源： Human Cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

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注意事项 Considerations

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