Recombinant Human LOX-1/OLR1,BR

产品属性 Product Attributes

基本信息

别名： Oxidized Low-Density Lipoprotein Receptor 1;Ox-LDL Receptor 1;C-Type Lectin Domain Family 8 Member A;Lectin-Like Oxidized LDL Receptor 1;LOX-1;Lectin-Like oxLDL Receptor 1;hLOX-1;Lectin-Type Oxidized LDL Receptor 1;OLR1;CLEC8A;LOX1
中文名称: Recombinant Human LOX-1/OLR1
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： Oxidized Low-Density Lipoprotein Receptor 1 (Ox-LDL Receptor 1) is a secreted，single-pass type II membrane protein which belongs to the C-type lectin superfamily.Ox-LDL Receptor 1 is expressed at high levels in endothelial cells and vascular-rich organs such as placenta，lung，liver，brain，aortic intima，bone marrow，spinal cord and substantia nigra.The expression of Ox-LDL Receptor 1 is induced by inflammatory cytokines such as TNF，IFNG and IL6 by pathological conditions，such as hyperlipidemia，hypertension and diabetes mellitus.Ox-LDL Receptor 1 mediates the recognition，internalization and degradation of oxidatively modified low density lipoprotein (OxLDL) by vascular endothelial cells.Ox-LDL Receptor 1 association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release，monocyte adhesion and apoptosis.Ox-LDL Receptor 1 also binds to oxLDL，which acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells，thereby participating in cell-mediated antigen cross-presentation.It also participates in inflammatory process，by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation.
来源： Human Cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

产品介绍 Product Introduction

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注意事项 Considerations

1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
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3.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。