Recombinant Mouse SEMA4D/Semaphorin-4D/CD100/Semacl2/Semaj,BR

产品属性 Product Attributes

基本信息

别名： SEMA4D;Semaphorin-4D;M-Sema G;Semaphorin-C-like 2;Semaphorin-J;Sema J;CD100;Semacl2;Semaj
中文名称: Recombinant Mouse SEMA4D/Semaphorin-4D/CD100/Semacl2/Semaj
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4.
纯度: ≥90% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： SEMA4D is a member of the semaphorin family，contains one Ig-like C2-type domain，one PSI domain and one Sema domain.SEMA4D is strongly expressed in lymphoid tissues，especially in the thymus，as well as in the nervous tissues.However，SEMA4D is expressed at lower levels in testes，brain，kidney，small intestine，prostate，heart，placenta，lung and pancreas，but not in colon and liver.SEMA4D is a cell surface receptor for PLXN1B and PLXNB2 that plays an important role in cell-cell signaling.SEMA4D is involved in a number of fundamental biological processes such as promoting reorganization of the actin cytoskeleton，the migration of cerebellar granule cells and of endothelial cells and signaling via SRC and PTK2B/PYK2，which then mediates activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade.Not only these，it plays a role in axonal growth cone guidance in the developing central nervous system.Semaphorin-4D / SEMA4D may play a functional role in the immune system，as well as in the nervous system.It could induce B-cells to aggregate and improves their viability (in vitro).SEMA4D is involved in regulating dendrite and axon branching and morphogenesis and promoting interaction with PLXNB1 mediates activation of RHOA.
来源： Human Cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

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注意事项 Considerations

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