Recombinant Mouse VSIG4,BR

产品属性 Product Attributes

基本信息

别名： Vsig4;V-set and immunoglobulin domain containing 4;
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： V-set and immunoglobulin domain containing 4 (VSIG4) is a type I transmembrane glycoprotein that is a B7 family-related protein and an Ig superfamily member.Mouse VSIG4 is synthesized as a 280 amino acid (aa) precursor that contains a signal sequence，an IgV-type immunological domain (aa 36-115)，one potential N-linked glycosylation site，and a single transmembrane domain.The IgV domain of mouse VSIG4 shares 86% and 80% aa sequence identity with the IgV domains of rat and human VSIG4，respectively.VSIG4 functions as a negative regulator of mouse as well as human T cell activation，and may be involved in the maintenance of peripheral T cell tolerance and/or unresponsiveness.VSIG4 acts as a macrophage complement receptor by binding complement fragments C3b and iC3b.VSIG4 binding to C3b inhibits complement activation through the alternative pathway，making it a potent suppressor of established inflammation.
来源： Human Cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

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