Recombinant Human DLL4,BR

产品属性 Product Attributes

基本信息

别名： Delta-like protein 4;Drosophila Delta homolog 4;Delta4;DLL4
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of 20mM Tris,150mM NaCl,pH8.0.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Powder:＜-20℃ for long store;RT，3 weeks.Liquid:4-7℃，2-7 days;＜-20℃，3 months.

产品信息

背景说明： Delta-like protein 4 (DLL4) is a type I membrane protein belonging to the Delta/Serrate/Lag2 (DSL) family of Notch ligands.In mammals，four Notch homologs (Notch 1 to4) and five ligands (DLL 1，3 and 4，Jagged 1 and 2) have been identified.DLL4 is expressed highly and selectively within the arterial endothelium and has been shown to function as a ligand for Notch 1 and Notch 4.Human and mouse DLL4 shares 86% amino acid sequence identity.Notch ligands are transmembrane proteins with a DSL motif necessary for Notch binding，tandem EGF repeats，a transmembrane region and a short intracellular domain (ICD).Notch ligands are categorized into two subfamilies based on the presence of an extracellular cysteinerich domain and insertions that interrupt some EGF repeats in the Jagged but not the Delta ligand family.Interactions of Notch receptors with their ligands result in reciprocal regulated intramembrane proteolysis (RIP).RIP is a mechanism for transmembrane signal transduction that involves the sequential processing by a disintegrin metalloprotease (ADAM) and then by presenilin/ γ secretase，resulting in shedding of the extracellular domains and the generation of the soluble ICD signaling fragments，respectively.
来源： Human Cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

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