Recombinant Mouse Lysosome-associated Membrane Glycoprotein 1/LAMP-1/CD107a,BR

产品属性 Product Attributes

基本信息

别名： Lysosome-associated membrane glycoprotein 1;LAMP-1;Lysosome-associated membrane protein 1;120 kDa lysosomal membrane glycoprotein;CD107 antigen-like family member A;LGP-120;Lysosomal membrane glycoprotein A;LGP-A;P2B;CD107a
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： Lysosomal associated membrane protein 1 (LAMP1) is an approximately 120 kDa transmembrane glycoprotein that is a major protein component of lysosomal membranes.Mature mouse LAMP1 consists of a 346 amino acid (aa) intralumenal domain (ECD)，a 24 aa transmembrane segment，and a 12 aa cytoplasmic tail.Its lumenal domain is organized into two heavily N-glycosylated regions separated by a Ser/Pro-rich linker that carries a minor amount of O-linked glycosylation.Within the lumenal domain，mouse LAMP1 shares approximately 64% and 82% aa sequence identity with human and rat LAMP1，respectively.The sorting of LAMP1 to lysosomes relies on a tyrosine motif in the cytoplasmic tail.In cytotoxic T cells and mast cells，LAMP1 is expressed in the membranes of intracellular granules that contain effector molecules such as perforin，granzymes，eicosanoids，and histamine.A glycoform of LAMP1 known as M150 is expressed on the surface of activated macrophages where it promotes T cell co-stimulation and a Th1 biased immune response.Exposure of epithelial cells to pathogenic Neisseria bacteria induces the redistribution of LAMP1 to the cell surface where it can be cleaved by the Neisseria IgA1 protease.
来源： Human Cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

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