Recombinant Mouse TNFRSF11B/Osteoprotegerin/OPG/Tumor Necrosis Factor Receptor Superfamily Member 11B,BR

产品属性 Product Attributes

基本信息

别名： Tumor necrosis factor receptor superfamily member 11B;Osteoclastogenesis inhibitory factor;Osteoprotegerin;Tnfrsf11b;Ocif;Opg
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： Osteoprotegerin (OPG，Tnfrsf11b) is a secreted protein that regulates bone density.OPG is widely expressed and constitutively released as a homodimer by mesenchymal stem cells，fibroblasts and endothelial cells.Regulation of its expression by estrogen，parathyroid hormone and cytokines is complex and changes with age.OPG acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis.TRAIL decreases the release of OPG from cells that express it，while OPG inhibits TRAIL-induced apoptosis.Expression of RANK L on the cell surface，and thus its ability to stimulate osteoclastogenesis，is regulated by OPG by intracellular and extracellular mechanisms.Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B.It may also play a role in preventing arterial calcification.
来源： Human Cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

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