Recombinant Human Receptor Tyrosine-protein Kinase ErbB-4/ErbB4/Her4,BR

产品属性 Product Attributes

基本信息

别名： Receptor tyrosine-protein kinase erbB-4;Proto-oncogene-like protein c-ErbB-4;Tyrosine kinase-type cell surface receptor HER4;p180erbB4;ERBB4;HER4
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： ErbB4 is a type I membrane glycoprotein that is a member of the ErbB family of tyrosine kinase receptors.ErbB family members serve as receptors for the epidermal growth factor (EGF) family of growth factors.ErbB4 is expressed in normal skeletal muscle，heart，pituitary，brain and several breast carcinomas.ErbB4 ligands include the neuregulins，beta-cellulin and heparin-binding EGFlike growth factor (HBEGF).Monomeric ErbB4 binds its ligands with low affinity.Several ErbB4 isoforms exist.Two of these differ in the presence of juxtamembrane extracellular sequences which regulate the ability of TACE (TNFα converting enzyme) to proteolytically cleave ErbB4 from the cell surface.These isoforms exhibit tissuespecific expression.Another isoform lacks the phosphoinositide 3kinase activation sequence present in the ErbB4 cytoplasmic domain.ErbB4 appears to play important roles in neuronal development，development of the heart and cancer.
来源： Human Cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

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