Recombinant Mouse CD31/PECAM-1/Platelet Endothelial Cell Adhesion Molecule,BR

产品属性 Product Attributes

基本信息

别名： Platelet endothelial cell adhesion molecule;PECAM-1;CD31;Pecam1;Pecam
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： Platelet endothelial cell adhesion molecule (PECAM-1，CD31) is a type I transmembrane glycoprotein adhesion molecule in the immunoglobulin superfamily.PECAM-1 is concentrated at cell junctions and is required for transendothelial migration (TEM).The extracellular domain (ECD) of PECAM-1 has ten potential N-linked glycosylation sites and six C2-type Ig-like domains，the first of which is critical for adhesion and extravasation.The cytoplasmic domain contains immunoregulatory tyrosine-based inhibitory and switch motifs (ITIM，ITSM) that mediate both inhibition and activation via phosphotyrosine-mediated engagement of SH2-containing signaling molecules.Expression is restricted to cells involved in circulation，especially endothelial cells，platelets，monocytes，neutrophils and lymphocyte subsets.PECAM-1 participates with other adhesion molecules in some functions，but is the critical molecule for TEM.Homotypic PECAM-1 adhesion in trans，combined with cycling of PECAM-1 to and from surface-connected endothelial cell vesicles，leads leukocytes across endothelial tight junctions.
来源： Human Cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

产品介绍 Product Introduction

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