Recombinant Human Angiopoietin-like Protein 3/ANGPTL3 (17-220aa),BR

产品属性 Product Attributes

基本信息

别名： Angiopoietin-related protein 3;ANGPTL3;Angiopoietin-5;ANG-5;Angiopoietin-like protein 3;ANGPT5
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： Angiopoietin-like 3 (ANGPTL3) is a secreted glycoprotein that is structurally related to the angiopoietins.Mature human ANGPTL3 contains an N-terminal coiled coil domain and a C-terminal fibrinogen-like domain.ANGPTL3 is expressed in the liver from early in development through adulthood.Full length ANGPTL3 circulates in the plasma as do the proteolytically separated N-and C-terminal segments containing the coiled coil domain and fibrinogen-like domains，respectively.ANGPTL3 directly inhibits lipoprotein lipase (LPL) and endothelial lipase (EL)，enzymes responsible for hydrolyzing circulating triglycerides and HDL phospholipids.ANGPTL3 promotes an increase in circulating triglyceride levels without altering VLDL or HDL secretion or uptake.ANGPTL3 expression in vivo is up-regulated by LXR agonists and down-regulated by insulin，leptin，and agonists of TRβ or PPARβ.
来源： Human Cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

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