Recombinant Mouse CD40 Ligand/TNFSF5/CD40L/CD154/T-cell antigen Gp39/gp39,BR

产品属性 Product Attributes

基本信息

别名： CD40 Ligand;CD40LG;HIGM1;T-B cell-activating molecule;T-BAM;TNFSF5;tumor necrosis factor (ligand) superfamily member 5;Tumor necrosis factor ligand superfamily member 5
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of 20mM PB, 200mM NaCl, 0.1mM EDTA, pH 7.0.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： CD40 Ligand，also known as TNFSF5，CD154，is a type II transmembrane glycoprotein member of the TNF superfamily.Mature mouse CD40 Ligand consists of a 22 amino acid (aa) cytoplasmic domain，a transmembrane segment，and a 214 aa extracellular region.CD40 Ligand is expressed as a homotrimer on platelets and activated T cells and B cells.It is up-regulated following stimulation of basophils，eosinophils，fibroblasts，mast cells，monocytes，natural killer cells，vascular endothelial cells，and smooth muscle cells.CD40 Ligand binds and activates CD40，which is expressed on the surface of B cells，dendritic cells，macrophages，monocytes，platelets，endothelial cells，and epithelial cells.Monomeric，dimeric，and trimeric forms of soluble CD40 Ligand bind to oligomeric CD40 on cell membranes.CD40 ligation by CD40 Ligand promotes B cell activation and T cell-dependent humoral responses.CD40 Ligand dysregulation on T cells and antigen presenting cells contributes to the immune deficiency associated with HIV infection and AIDS.It is also implicated in the pathology of multiple cardiovascular diseases including atherosclerosis，atherothrombosis，and restenosis.
来源： Human Cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

产品介绍 Product Introduction

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