Recombinant Human TREM-2/Triggering Receptor Expressed On Myeloid 2,BR

产品属性 Product Attributes

基本信息

别名： Triggering receptor expressed on myeloid cells 2;TREM-2;Triggering receptor expressed on monocytes 2;TREM2
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： Triggering Receptor Expressed on Myeloid cells 2 (TREM2)is a 35 kDa type I transmembrane member of the TREM family and Ig superfamily.Mature human TREM2 consists of a 156 amino acid (aa) extracellular domain (ECD) with one V-type Ig-like domain，a 21 aa transmembrane (TM) domain，and a 35 aa cytoplasmic tail.Soluble forms of the TREM2 ECD are generated by alternative splicing or proteolytic cleavage，and the cytoplasmic domain can be liberated by gamma-Secretase mediated intramembrane cleavage.A positively charged lysine within the transmembrane segment allows association with the signal adapter protein，DAP12 and inhibition of macrophage activation.TREM2 is expressed on macrophages，immature myeloid dendritic cells，osteoclasts，microglia，and adipocytes.It promotes the differentiation and function of osteoclasts，the production of inflammatory cytokines by adipocytes，insulin resistance，and the phagocytic clearance of bacteria.
来源： Human Cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

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