Recombinant Human SLAMF3/T-lymphocyte Surface Antigen Ly-9/CD229,BR

产品属性 Product Attributes

基本信息

别名： T-lymphocyte surface antigen Ly-9;Cell surface molecule Ly-9;Lymphocyte antigen 9;SLAM family member 3;SLAMF3;Signaling lymphocytic activation molecule 3;CD229;Ly9
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： SLAMF3 (CD229) is a type I transmembrane glycoprotein in the SLAM subgroup of the CD2 family.Mature human SLAMF3 consists of a 407 amino acid (aa) extracellular domain (ECD) with two Ig-like V-set and two Ig-like truncated C2-set domains.The ECD of human SLAMF3 shares 57% - 59% aa sequence identity with mouse and rat SLAMF3.Within the first two Ig-like domains that are common to all SLAM proteins，human SLAMF3 shares 24% - 39% aa sequence identity with human 2B4，BLAME，CD2F-10，CD84，CRACC，NTB-A，and SLAM.It is expressed on T and B cells，thymocytes，and more weakly on NK cells.It may participate in adhesion reactions between T lymphocytes and accessory cells by homophilic interaction.Promotes T-cell differentiation into a helper T-cell Th17 phenotype leading to increased IL-17 secretion; the costimulatory activity requires SH2D1A.SLAMF3 may be involved in the maintenance of peripheral cell tolerance by serving as a negative regulator of the immune response.It also disable autoantibody responses and inhibit IFN-gamma secretion by CD4+ T-cells and negatively regulate the size of thymic innate CD8+ T-cells and the development of invariant natural killer T (iNKT) cells.
来源： Human Cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/μg(1 EU/μg)as determined by LAL test.

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