Recombinant Human Apoptosis Regulator Bcl-2/B-cell Lymphoma 2,BR

产品属性 Product Attributes

基本信息

别名： Apoptosis regulator Bcl-2;BCL2
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Supplied as a 0.2 μm filtered solution of 20mM HEPES, 150mM NaCl, 10%Glycerol, pH8.0.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Store at≤-70℃，6 months.with seal;3 month after opening.Avoid freeze/thaw cycles.

产品信息

背景说明： Bcl-2 is a member of a family of proteins that regulates outer mitochondrial membrane permeability.Bcl-2 is an antiapoptotic member that prevents release of cytochrome c from the mitochondria intermembrane space into the cytosol.Bcl-2 is present on the outer mitochondrial membrane and is also found on other membranes in some cell types.BCL-2 is localized to the outer membrane of mitochondria，where it plays an important role in promoting cellular survival and inhibiting the actions of pro-apoptotic proteins.The pro-apoptotic proteins in the BCL-2 family，including Bax and Bak，normally act on the mitochondrial membrane to promote permeabilization and release of cytochrome C and ROS，that are important signals in the apotosis cascade.These pro-apoptotic proteins are in turn activated by BH3-only proteins，and are inhibited by the function of BCL-2 and its relative BCL-Xl.
来源： E.coli

其它标识

内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

产品介绍 Product Introduction

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