Recombinant Mouse TIM-3/Havcr2,BR

产品属性 Product Attributes

基本信息

别名： Hepatitis A virus cellular receptor 2 homolog;HAVcr-2;T-cell immunoglobulin and mucin domain-containing protein 3;T-cell immunoglobulin mucin receptor 3;T-cell membrane protein 3;Tim3;Timd3
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： T cell immunoglobulin and mucin domain-3 (TIM3)，also called hepatitis A virus cellular receptor 2 (HAVCR2)，is a transmembrane glycoprotein of the TIM family of immune regulating molecules and plays an important role in the Th1-mediated immune response.TIM3 is expressed on the Th1 cells，CD8 T-cells，monocytes，and dendritic cells，but not on Th2 cells.TIM3 expressed by monocytes and dendritic cells facilitates phagocytosis of apoptotic cells and up-regulates cross-presentation of apoptotic cell-associated antigens through interaction with phosphatidylserine.Engagement of TIM3 by its ligand galectin-9 induces a range of immunosuppressive functions which enhance immune tolerance and inhibit anti-tumor immunity.Stimulation of TIM3 with an agonistic antibody promotes inflammation through the activation of innate immune cells.TIM3 is also regarded as a potential target molecule for immunotherapy.TIM3 and programmed cell death 1 (PD-1) as two important coinhibitory regulators of T cell responses，have been implicated with the T-cell dysfunction or exhaustion associated with chronic HBV infection including HBV-related HCC.
来源： Human Cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

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