Recombinant Human NKG2D Ligand 1/NKG2DL/ULBP1,BR

产品属性 Product Attributes

基本信息

别名： NKG2D ligand 1;N2DL-1;NKG2DL1;ALCAN-beta;Retinoic acid early transcript 1I;UL16-binding protein 1;ULBP1
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： ULBP1，also known as RAET1I and NKG2DL1，is a member of the ULBP/RAET1 gene family.ULBP1 plays an important role in immune responses，especially in cancer and infectious diseases，and is well-known to bind to NKG2D together with at least ULBP 2 and 3.These proteins are distantly related to major histocompatibility class I (MHC I) molecules，possessing the alpha 1 and alpha 2 Ig-like domains，but lacking the alpha 3 domain.Unlike MHC Class I，they have no capacity to bind peptide or interact with beta2-microglobulin.It can activate multiple signaling pathways in primary NK cells，gamma delta T cells，and CD8+ alpha beta T cells，resulting in the production of cytokines and chemokines.ULBP1 is expressed in wide range of tissues including heart，brain，lung，liver，bone marrow and some tumor cells，T-cells，B-cells，As an unconventional member of the MHC class I family，ULBP1 is able to interact with soluble CMV glycoprotein UL16 in CMV infected cells.The interaction with UL16 blocked the interaction with the NKG2D receptor，and thus might escape the immune surveillance.Furthermore，UL16 also causes ULBP1 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface.The ULBP1 regulation may have implications for development of new therapeutic strategies against cancer cells.
来源： Human Cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

产品介绍 Product Introduction

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