Recombinant Mouse IL-12RB2/IL-12R β2,BR

产品属性 Product Attributes

基本信息

别名： IL12RB2;IL-12 receptor beta 2;IL-12 receptor subunit beta-2;IL-12R subunit beta-2;IL-12RB2;IL-12R-beta-2;interleukin-12 receptor beta-2 chain;interleukin-12 receptor subunit beta-2
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： The IL12 receptor complex，formed by IL12RB1 and IL12RB2，mediates the type I immune responses of various types of lymphocytes.Its ligand，IL12，is a heterodimeric cytokine composed of IL-12p35 and IL-12p40 subunits that are linked via disulfide bonds.Ligation of IL-12 to its receptor involves the binding of IL-12p35 to IL12RB1 and IL-12p40 to IL12RB2.This will result in the activation of tyrosine kinase 2 (TYK2)，which is associated with the IL12RB1 chain and Janus kinase 2 (JAK2)，which is associated with the IL12RB2 chain.Activated TYK2 and JAK2 direct the phosphorylation of STAT4.IL12RB1 is present on all lymphocytes，while the expression of IL12RB2 is tightly regulated.It has shown that the expression of IL12RB2 is limited to Th2 cells.IL12RB2 subunit plays an important role in Th1 cell differentiation，since its absence leads to an abortive Th1 differentiation that has dysfunctional production of Th1 effector molecules.
来源： Human Cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

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