Recombinant Mouse Triggering Receptor Expressed on Myeloid Cells 2b/TREM-2b,BR

产品属性 Product Attributes

基本信息

别名： Triggering Receptor Expressed on Myeloid Cells 2b;Triggering receptor expressed on myeloid cells 2;TREM-2;Triggering receptor expressed on monocytes 2;Trem2;Trem2a;Trem2b;Trem2c;TREM-2b
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： Triggering receptor expressed on myeloid cells-2 (TREM-2) is a cell surface receptor primarily expressed on macrophages，osteoclasts，microglia and dendritic cells.TREM-2 is one member of the TREM family，inhibiting the releasing of inflammatory mediators，so it is an important in vivo anti-inflammatory receptor.TREM-2 consists of an 18 aa signal sequence，a 153 aa extracellular domain (ECD) with one V-type Ig-like domain，a 21 aa transmembrane (TM) domain，and a 35 aa cytoplasmic tail.A soluble form of TREM-2 (TREM-2b) created by alternate splicing diverges at aa 161.TREM-2 transduces intracellular signals through the adaptor DAP12.After binding of TREM-2 with ligand，the TREM-2/DAP12 (dead-cell-activated-receptor-associated protein)-mediated signal transduction pathway causes a series of intracellular protein tyrosine phosphorylation reactions and enzymatic reactions，which then activate the myeloid cells and participate T cell responses.
来源： Human Cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

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