Recombinant Human NKG2D/CD314/NKG2-D type II Integral Membrane Protein/KLRK1,BR

产品属性 Product Attributes

基本信息

别名： CD314;KLRK1;CD314 antigen;Killer cell lectin-like receptor subfamily K member 1;killer cell lectin-like receptor subfamily K;member 1;KLR;NK cell receptor D;NKG2-D;NKG2-D type II integral membrane protein;NKG2-D-activating NK receptor;NKG2D
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： NKG2-D type II integral membrane protein (NKG2D) is a type II transmembrane glycoprotein which belongs to the CD94/NKG2 family.NKG2D is expressed on natural killer (NK) cells，CD8+ alpha-beta and gamma-delta T-cells.As an activating and costimulatory receptor，it involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells.It provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells，leading to cytotoxic activity.It stimulates perforin-mediated elimination of ligand-expressing tumor cells.Signaling involves calcium influx，culminating in the expression of TNF-alpha.NKG2D participates in NK cell-mediated bone marrow graft rejection and survival of NK cells.It Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins including MICA，MICB，RAET1E，RAET1G，ULBP1，ULBP2，ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4.
来源： Human Cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/μg(1 EU/μg)as determined by LAL test.

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