Recombinant Human Glypican-1/GPC1,BR

产品属性 Product Attributes

基本信息

别名： Glypican-1;GPC1
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： The Glypicans are a small multigene family of GPI-linked proteoglycans that play a key role in growth factor signaling.Human Glypican 1 (GPC1) is synthesized as a 558 amino acid (aa) preproprecursor that contains a 23 aa signal sequence，a 507 aa mature segment，and a 28 aa C-terminal prosegment.There are two potential N-linked and four potential O-linked sites for glycosylation or glycanation.There are potentially two heparan sulfate (HS) modifications on GPC1 that could contribute to a native molecular weight of approximately 200 kDa.Mature human GPC1 shares 91% aa identity with mature mouse GPC1.Cells known to express GPC1 include neurons，smooth and skeletal muscle cells，keratinocytes，osteoblasts，Schwann cells，immature dendritic cells，and tumor，plus tumorassociated vascular endothelial cells.The function of GPC1 is complex and varied.As a proteoglycan，it appears to make use of its HS adduct to impact select growth factor activity.This is accomplished by having juxtramembrane HS attachment sites，and a flexible，GPI-linkage.
来源： Human Cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

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