Recombinant Mouse ICOS Ligand/B7-H2/CD275,BR

产品属性 Product Attributes

基本信息

别名： B7 homolog 2;B7-H2;B7-like protein Gl50;B7RP-1LICOS;CD275;CD275 antigen;ICOS ligand;ICOSL;ICOS-L;inducible T-cell co-stimulator ligand;B7RP-1;CD275;GL50;ICOSL;ICOSLG;B7H2;B7RP1
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： Mouse ICOS ligand(B7-H2) is an approximately transmembrane glycoprotein in the B7 family of immune regulatory molecules.B7-H2 is expressed on antigen presenting cells such as B cells，macrophages，monocytes，and dendritic cells.It binds to ICOS on activated T cells，leading to both positive and negative effects on immune responses including its own down-regulation.The B7-H2 interaction with ICOS is costimulatory for T cell proliferation as well as the development of B cells，plasma cells，follicular helper T cells and germinal centers.B7-H2 contributes to the development of allergic asthma by enhancing Th2 biased immune responses，limiting Th17 responses，and promoting eosinophilic infiltration into the lung.Its activation of ICOS on Treg limits pulmonary inflammation and airway hyperresponsiveness，promotes the development of inhalational tolerance，and impairs antitumor immunity.In the thyroid，B7-H2 is up-regulated on thyrocytes during inflammation and promotes their proliferation and production of thryoid hormones.
来源： Human Cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

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