Recombinant Mouse CD155/PVR/Poliovirus Receptor/Nectin-Like Protein 5/NECL-5/PVS,BR

产品属性 Product Attributes

基本信息

别名： Poliovirus receptor;CD155 antigen;Nectin-like protein 5;Nectin-2;Tage4 receptor;Pvr;PVR;Necl5;CD155
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Powder:＜-20℃ for long store;RT，3 weeks.Liquid:4-7℃，2-7 days;＜-20℃，3 months.

产品信息

背景说明： Mouse poliovirus receptor (PVR，CD155) is a type I transmembrane (TM) glycoprotein that is a member of the nectin-related family of adhesion proteins within the immunoglobulin superfamily.It binds other molecules including vitronectin，Nectin3，DNAM1，CD96，and TIGIT，but does not bind homotypically.CD155 includes a 28 aa signal sequence，a 318 aa extracellular domain (ECD) with one N-terminal V-type and two C2-type Ig-like domains，a 24 aa TM segment and a 38 aa cytoplasmic tail.Epithelial，endothelial，and many immune cells show low CD155 expression.It is up-regulated on endothelia by IFNγ，and is highly expressed on immature thymocytes，lymph node dendritic cells，and tumor cells of epithelial and neuronal origin.On migrating cells，it is concentrated at the leading edge，where it binds basement membrane vitronectin，recruits Nectin-3-expressing cells，and cooperates with PDGF and integrin αvβ3 to promote cell migration.Binding of monocyte DNAM-1 to endothelial cell CD155 promotes transendothelial migration.Enhanced CD155 expression in tumor cells contributes to loss of contact inhibition and increased migration，but also allows tumor cell recognition and killing by DNAM-1or CD96 expressing NK cells.
来源： Human Cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

产品介绍 Product Introduction

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