Recombinant Human CD28/TP44/T-cell-specific surface glycoprotein CD28,BR

产品属性 Product Attributes

基本信息

别名： CD28;CD28 antigen;CD28 molecule;T-cell-specific surface glycoprotein CD28;Tp44;TP44
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： T-cell-specific surface glycoprotein CD28(CD28) is a single-pass typeI membrane protein which contains one Ig-likeV-type (immunoglobulin-like)domain.It belongs to the immunoglobulin(Ig) superfamily.CD28 is one of the molecules expressed on T cells that provide co-stimulatory signals，which are required for T cell activation.CD28 co-stimulation is necessary for CD4 positive T-cell proliferation and survival，interleukin-2 production，and T-helper type-2 development.Human post-thymic regulatory T cells require CD28 co-stimulation to expand and maintain potent suppressive function in vivo.Apoptosis plays a key role in the age-related decline of CD28 expression and in immunosenescence.CD28 is the receptor for CD80(B7.1) and CD86(B7.2).When activated by Toll-like receptor ligands，the CD80 expression is upregulated in antigen presenting cells(APCs).The CD86 expression on antigen presenting cells is constitutive.CD28 is the only B7 receptor constitutively expressed on naive T cells.
来源： Human Cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

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