Recombinant Human NRG1-beta 1/HRG1-beta 1 ECD/NRG1/Pro-neuregulin-1/NRG1 beta 1 ECD Protein/Neuregulin1 beta 1; Neuregul,BR

产品属性 Product Attributes

基本信息

别名： Pro-neuregulin-1;Neuregulin-1 beta 1;NRG1-beta 1;HRG1-beta 1;EGF;NRG1;GGF;HGL;HRGA;NDF;SMDF;
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： Pro-neuregulin-1，Neuregulin-1 beta 1（NRG1） is a single-pass type I membrane protein and belongs to the neuregulin family.It contains 1 EGF-like domain and 1 Ig-like C2-type (immunoglobulin-like) domain.Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors.The protein concomitantly recruits ERBB1 and ERBB2 coreceptors，resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors.The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial，glial，neuronal，and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart.Isoform 10 may play a role in motor and sensory neuron development.
来源： E.coli

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

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