Recombinant Mouse Cell adhesion molecule 1/CADM1,BR

产品属性 Product Attributes

基本信息

别名： Cell adhesion molecule 1;Immunoglobulin superfamily member 4;IgSF4;Nectin-like protein 2;NECL-2;Synaptic cell adhesion molecule;SynCAM;Tumor suppressor in lung cancer 1;TSLC-1
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： Cell adhesion molecule 1(CADM1) is a single-pass type I membrane protein and belongs to the nectin family.It contains 2 Ig-like C2-type (immunoglobulin-like) domains and 1 Ig-like V-type (immunoglobulin-like) domain.CADM1 acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells.Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo.CADM1 may contribute to the less invasive phenotypes of lepidic growth tumor cells.In mast cells，it may mediate attachment to and promote communication with nerves.CADM1，together with MITF，is essential for development and survival of mast cells in vivo.The protein acts as a synaptic cell adhesion molecule and plays a role in the formation of dendritic spines and in synapse assembly.It may be involved in neuronal migration，axon growth，pathfinding，and fasciculation on the axons of differentiating neurons.CADM1 may play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa.
来源： Human Cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

产品介绍 Product Introduction

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