Recombinant Human Endothelial cell-selective adhesion molecule/ESAM,BR

产品属性 Product Attributes

基本信息

别名： Endothelial Cell-Selective Adhesion Molecule;ESAM
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： Endothelial Cell Adhesion Molecule (ESAM) is a 55 kDa type I transmembrane glycoprotein member of the JAM family of immunoglobulin superfamily molecules.The 390 amino acid Human ESAM contains a 216 amino acid extracellular domain (ECD) with a V-type and a C2-type immunoglobulin (Ig) domain.The ECD of human and mouse ESAM share 69% amino acid identity.ESAM is specifically expressed at endothelial tight junctions and on activated platelets and performs homophilic adhesion activity.The adaptor protein membrane-associated guanylate kinase MAGI-1 has been identified as an intracellular binding partner of ESAM.In addition，ESAM at endothelial tight junctions participates in the migration of neutrophils through the vessel wall，possibly by influencing endothelial cell contacts.ESAM-deficient mice were described with lowered angiogenic potential，and accordingly，overexpression of ESAM is closely associated with certain tumor growth and metastasis.
来源： Human Cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

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