Recombinant Human Methionine Aminopeptidase 2/METAP2/MAP2,BR

产品属性 Product Attributes

基本信息

别名： Methionine aminopeptidase 2;MAP 2;MetAP 2;p67;p67eIF2;Peptidase M;METAP2;MAP2
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Supplied as a 0.2 μm filtered solution of 20mM Tris, 500mM NaCl, 10% glycerol, pH8.0.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.

产品信息

背景说明： Human Methionine Aminopeptidase 2 (METAP2，MAP2) is a member of the M24 family of metalloproteases.METAPs catalyze the removal of the initiatormethionine residue from nascent peptides and are essential for cell growth.MAP2 binds 2 cobalt or manganese ions and contains approximately 12 O-linked N-acetylglucosamine (GlcNAc) residues.It is found in all organisms and is especially important because of its critical role in tissue repair and protein degradation.METAP2 plays an important role in the development of different types of cancer and has been a novel target for developing anti-cancerdrugs.This protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation and by removing the amno-terminal methionine residue from nascent protein.MAP2 protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR.It also plays a critical role in the regulation of protein synthesis.
来源： Baculovirus

其它标识

内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

产品介绍 Product Introduction

暂无数据

注意事项 Considerations

1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
3.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。