Recombinant Human STUB1/CHIP,BR

产品属性 Product Attributes

基本信息

别名： E3 Ubiquitin-Protein Ligase CHIP;Antigen NY-CO-7;CLL-Associated Antigen KW-8;Carboxy Terminus of Hsp70-Interacting Protein;STIP1 Homology and U Box-Containing Protein 1;STUB1;CHIP
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Supplied as a 0.2 μm filtered solution of PBS, PH7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.

产品信息

背景说明： E3 Ubiquitin-Protein Ligase CHIP is a cytoplasmic protein.CHIP is highly expressed in skeletal muscle，heart，pancreas，brain and placenta.CHIP interacts with the molecular chaperones Hsc70-Hsp70 and Hsp90 through its TPR domain; lead to in client substrate ubiquitylation and degradation by the proteasome.CHIP targets misfolded chaperone substrates towards proteasomal degradation.CHIP mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation.CHIP plays a role in base-excision repair: catalyzes polyubiquitination by amplifying the HUWE1/ARF-BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome.It also may regulate the receptor stability and activity through proteasomal degradation.
来源： E.coli

其它标识

内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

产品介绍 Product Introduction

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注意事项 Considerations

1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
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3.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。