Recombinant Human EGFRvIII,BR

产品属性 Product Attributes

基本信息

别名： Epidermal growth factor receptor;EGFR;Proto-oncogene c-ErbB-1;Receptor tyrosine-protein kinase erbB-1;EGFR
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： The EGFR subfamily of receptor tyrosine kinases is composed of EGFR，ErbB2，ErbB3 and ErbB4.The EGFR shares 43% - 44% aa sequence identity with the ECD of human EGFR subfamily.All these family members are type I transmembrane glycoproteins with an extracellular ligand binding domain.The extracellular ligand binding domain is containing two cysteine-rich domains separated by a spacer region and a cytoplasmic domain containing a membrane-proximal tyrosine kinase domain.Ligand binding could induce EGFR homodimerization and heterodimerization with ErbB2，resulting in cell signaling，heterodimerization tyrosine phosphorylation and kinase activation.It can bind EGF，amphiregulin，TGF-alpha，betacellulin，epiregulin，HB-EGF，epigen，and so on.Its signaling regulates multiple biological functions including cell proliferation，differentiation，motility，and apoptosis.EGFR can also be recruited to form heterodimers with the ligand-activated ErbB3 or ErbB4.EGFR is overexpressed in different tumors.Several anti-cancer drugs use EGFR as target.
来源： Human Cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

产品介绍 Product Introduction

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