Recombinant Mouse IGFBP-7/Igfbp7,BR

产品属性 Product Attributes

基本信息

别名： Insulin-like growth factor-binding protein 7;IGFBP7;IGF-binding protein 7;IGFBP-rP1;MAC25 protein;Tumor-derived adhesion factor;TAF
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of PBS,150mM Nacl,pH7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： Insulin-like growth factor-binding protein 7(IGFBP-7) is a secreted glycosylated protein that contains three protein domain modules.IGFBP7 contains an N-terminal IGFBP domain，followed by a Kazal-type serine proteinase inhibitor domain and a C-terminal immunoglobulin-like C2-type domain.Human and mouse IGFBP7 are highly homologous and share 94% aa sequence identity.It is expressed in many normal tissues and in cancer cells.It is abundantly expressed in high endothelial venules (HEVs) of blood vessels in the secondary lymphoid tissues.It binds IGF and insulin with very low affinity and has been shown to enhance the mitogenic actions of IGF and insulin.IGFBP7 also has IGF/insulin-independent activities.It interacts with heparan sulfate proteoglycans，type IV collagen，and specific chemokines.It supports weak cell adhesion，promotes cell spreading on type IV collagen，and stimulates the production of the potent vasodilator PGI2.It modulates tumor cell growth and has also been implicated in angiogenesis.
来源： Human Cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

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