Recombinant Human Noggin/NOG,BR

产品属性 Product Attributes

基本信息

别名： Noggin;NOG
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of 20mM PB, 500mM NaCl, 2mM EDTA, pH 7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： Noggin is a secreted homodimeric glycoprotein that is an antagonist of bone morphogenetic proteins (BMPs).Mature Human Noggin contains an N-terminal acidic region，a central basic heparin-binding segment and a C-terminal cysteine-knot structure.Noggin is very highly conserved among vertebrates，such that mature human Noggin shares 99%，99%，98%，97% and 89% aa sequence identity with mouse，rat bovine，equine and chicken Noggin，respectively.Secreted Noggin probably remains close to the cell surface due to its binding of heparin-containing proteoglycans.Noggin binds some BMPs such as BMP4 with high affinity and others such as BMP7 with lower affinity.It antagonizes BMP bioactivities by blocking epitopes on BMPs that are needed for binding to both type I and type II receptors.Noggin is expressed in defined areas of the adult central nervous system and peripheral tissues such as lung，skeletal muscle and skin.During culture of human embryonic stem cells (hESC) or neural stem cells under certain conditions，addition of Noggin to antagonize BMP activity may allow stem cells to proliferate while maintaining their undifferentiated state，or alternatively，to differentiate into dopaminergic neurons.
来源： Human Cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

产品介绍 Product Introduction

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