Recombinant Human APRIL/TNFSF13/CD256/TALL2,BR

产品属性 Product Attributes

基本信息

别名： Tumor necrosis factor ligand superfamily member 13;A proliferation-inducing ligand;APRIL;TNF- and APOL-related leukocyte expressed ligand 2;TALL-2;TNF-related death ligand 1;TRDL-1;CD256;TNFSF13
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： APRIL (a proliferation-inducingligand)，also known as TNFSF13，TALL2，TRDL1，and CD256，is a member of the TNF ligand superfamily.It is synthesized as a32 kDa proprotein which is cleaved by furin in the Golgi to release the active 17 kDa soluble molecule.Secreted human APRIL，which consists almost entirely ofa single TNF homology domain，shares 85% amino acid sequence identity with mouse and rat APRIL.Both APRIL and its close relative BAFF bind and signalthrough the TNF superfamily receptors TACI and BCMA，while BAFF additionally functions through BAFF R.APRIL binds to heparan sulfateproteoglycans (HSPGs) independently of its binding to TACI and BCMA.APRIL can form bioactive heterotrimers withBAFF，and these circulate in the serum of patients with rheumatic immune disorders.APRIL enhances the proliferation and survival of plasma cells andalso promotes T cell-dependenthumoral responses.APRIL levels are elevated inthe serum during coronary artery disease，and it is also elevated in many cancers primarily due to expression by tumor-infiltratingneutrophils.
来源： Human Cells

其它标识

溶剂: Dissolve the lyophilized protein in distilled water.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

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