Recombinant Mouse Mesothelin/MPF/MSLN/CAK1/Mes,BR

产品属性 Product Attributes

基本信息

别名： Mesothelin;Msln;Mes;Mpf
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： Mesothelin is derived from a 70 kDa precursor that also includes Megakaryocyte Potentiating Factor (MPF).The 70 kDa precursor is expressed on the cell surface where it is cleaved at a dibasic proteolytic site to release the 32 kDa glycosylated MPF.MPF is a cytokine that potentiates IL3 induced megakaryocyte colony formation.The term Mesothelin refers to the 40 kDa glycosylated protein which remains attached to the cell surface via a GPI linkage.Mesothelin is over expressed in several human tumors，including mesothelioma and ovarian and pancreatic adenocarcinoma.The interaction between mesothelin and MUC16 (also known as CA125) may facilitate the implantation and peritoneal spread of tumors by cell adhesion.The region (296-359) consisting of 64 amino acids at the N-terminal of cell surface mesothelin is the functional binding domain for MUC16.Mesothelin is a tumour differentiation antigen that is normally present on the mesothelial cells lining the pleura，peritoneum and pericardium.A soluble form of Mesothelin，with its GPI anchor intact，is released from tumor cells and binds to MMR/CD206 on macrophages.
来源： Human Cells

其它标识

溶剂: Dissolve the lyophilized protein in distilled water.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

产品介绍 Product Introduction

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