Recombinant Cynomolgus CD3E/CD3ε/T-cell surface glycoprotein CD3 epsilon chain,BR

产品属性 Product Attributes

基本信息

别名： CD3 epsilon;CD3e antigen;CD3e antigen,epsilon polypeptide (TiT3 complex);CD3e molecule,epsilon (CD3-TCR complex);CD3e;CD3-epsilon;FLJ18683;T3E;T-cell antigen receptor complex,epsilon subunit of T3;T-cell surface antigen T3/Leu-4 epsilon chain;T-cell surface glycoprotein CD3 epsilon chain;TCRE
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of 50 mM Tris-HCl, 100 mM Glycine, pH 7.5.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： T-cell surface glycoprotein CD3 epsilon chain，also known as CD3E，is a single-pass type I membrane protein.CD3E contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain.CD3E，together with CD3-gamma，CD3-delta and CD3-zeta，and the T-cell receptor alpha/beta and gamma/delta heterodimers，forms the T cell receptor-CD3 complex.The CD3 epsilon subunit of the T cell receptor (TCR) complex contains two defined signaling domains，a proline-rich sequence and an immune tyrosine activation motifs (ITAMs)，and this complex undergoes a conformational change upon ligand binding that is thought to be important for the activation of T cells.T cell receptor-CD3 complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways.This complex is critical for T-cell development and function，and represents one of the most complex transmembrane receptors.CD3E plays an essential role in T-cell development，and defects in CD3E gene cause severe immunodeficiency.Homozygous mutations in CD3D and CD3E genes lead to a complete block in T-cell development and thus to an early-onset severe combined immunodeficiency phenotype.
来源： Human Cells

其它标识

溶剂: Dissolve the lyophilized protein in distilled water.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

产品介绍 Product Introduction

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注意事项 Considerations

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