Recombinant Human CD46,BR

产品属性 Product Attributes

基本信息

别名： Membrane Cofactor Protein;TLX;Trophoblast Leukocyte Common Antigen;CD46;MCP;MIC10
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： CD46 is a type I membrane protein containing four Sushi domains.CD46 is expressed by all cells except erythrocytes.CD46 has cofactor activity for inactivation of complement components C3b and C4b by serum factor I，which protects the host cell from damage by complement.It may be involved in the fusion of the spermatozoa with the oocyte during fertilization.CD46 also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells.T-regulatory 1 cells suppress immune responses by secreting interleukin-10，and therefore are thought to prevent autoimmunity.A number of viral and bacterial pathogens exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.CD46 acts as a receptor for the Edmonston strain of measles virus，human herpesvirus-6，and type IV pili of pathogenic Neisseria.
来源： Human Cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

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注意事项 Considerations

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