Recombinant Human Vanin-1/Pantetheinase/VNN1,BR

产品属性 Product Attributes

基本信息

别名： Pantetheinase;Pantetheine Hydrolase;Tiff66;Vascular Non-Inflammatory Molecule 1;Vanin-1;VNN1
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： Vanin-1 is a cell membrane protein which contains one CN hydrolase domain and belongs to the CN hydrolase family and BTD/VNN subfamily.Vanin-1 is also a member of the Vanin family of proteins，which share extensive sequence similarity with each other，and also with biotinidase.The family includes secreted and membrane-associated proteins，a few of which have been reported to participate in hematopoietic cell trafficking.Vanin-1 is widely expressed with higher expression in spleen，kidney and blood and overexpressed in lesional psoriatic skin.No biotinidase activity has been demonstrated for any of the vanin proteins; however，they possess pantetheinase activity，which may play a role in oxidative-stress response.Vanin-1 is an epithelial pantetheinase that provides cysteamine to tissue and regulates response to stress.Vanin-1 is expressed by enterocytes，and its absence limits intestinal epithelial cell production of proinflammatory signals.Vanin-1 regulates late adhesion steps of thymus homing under physiological，noninflammatory conditions.The early impact of vanin-1 deficiency on tumor induction was directly correlated to the amount of inflammation and subsequent epithelial proliferation rather than cell death rate.Vanin-1 molecule was shown to be involved in the control of thymus reconstitution following sub-lethal irradiation.
来源： Human Cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

产品介绍 Product Introduction

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