Recombinant Human IL-25/IL-17E,BR

产品属性 Product Attributes

基本信息

别名： Interleukin-25;IL-25;Interleukin-17E;IL-17E;IL25;IL17E
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of 20mM Tris-HCl,150mM NaCl 1mM EDTA,pH8.0.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： Interleukin 25 (IL-25) belongs to the Interleukin 17 (IL-17) family of proteins，which is comprised of six members (IL-17，IL-17B through IL-17F).These proteins are secreted and are structurally related by sharing a conserved cysteine-knot fold near the C-terminus，but have considerable sequence divergence at the N-terminus.With the exception of IL-17B，which exists as a non-covalently linked dimer，all IL-17 family members are disulfide-linked dimers.IL-17 family proteins are pro-inflammatory cytokines that induce local cytokine production and are involved in the regulation of immune functions.Human interleukin-17E (IL17E)，also referred to as Interleukin-25 (IL25)，is a distinct member of the IL17 cytokine family comprised of at least six members sharing a conserved cysteine-knot structure but divergent at the N-terminus.IL25 is a glycoprotein secreted as dimers by innate effector eosinophils and basophils，and present at very low levels in various peripheral tissues.IL25，together with IL17B，are ligands for the cytokine receptor IL17BR，and the cross-linking induces NF-κB activation and production of the proinflammatory chemokine IL-8，as well as ERK，JNK，and p38 activation.Overexpression of IL25 gene in transgenic mice suggested that this cytokine can regulate hematopoietic and immune functions，and additionally is identified as a proinflammatory cytokine favoring Th2-type immune responses possibly by enhancing the maintenance and functions of adaptive Th2 memory cells.
来源： Human Cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

产品介绍 Product Introduction

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