Recombinant Cynomolgus Fc gamma RIIIA/CD16a/FCGR3A,BR

产品属性 Product Attributes

基本信息

别名： Low Affinity Immunoglobulin Gamma Fc Region Receptor III-A;CD16a Antigen;Fc-Gamma RIII-Alpha;Fc-Gamma RIII;Fc-gamma RIIIa;FcRIII;FcRIIIa;FcR-10;IgG Fc Receptor III-2;CD16a;FCGR3A;CD16A;FCG3;FCGR3;IGFR3
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： Receptors for the Fc region of immunoglobin G (FcγR) are divided into three classes and FcγRIII is a multifunctional，low/intermediate affinity receptor.In humans，FcγRIII is expressed as two distinct forms (FcγRIIIA and FcγRIIIB) that are encoded by two different but highly homologous genes in a cell type-specific manner.FcγRIIIB is a low-affinity，GPI-linked receptor expressed by neutrophils and eosinophils，whereas FcγRIIIA is an intermediate affinity polypeptide-anchored transmembrane glycoprotein expressed by a subset of T lymphocytes，natural killer (NK) cells，monocytes，and macrophages.The FcγRIIIA receptor is involved in phagocytosis，secretion of enzymes，inflammatory mediators，antibody-dependent cellular cytotoxicity (ADCC)，mast cell degranulation，and clearance of immune complexes.FcγRIIIA has an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain and delivers an activation signal in the immune responses.Aberrant expression or mutations in this gene is implicated in susceptibility to recurrent viral infections，systemic lupus erythematosus，and alloimmune neonatal neutropenia.In humans，it is a 50 -70 kD type I transmembrane activating receptor.The FcγRIIIA cDNA encodes 254 amino acid including a 16aa signal sequence，191 amino acid ECD with two C2-type Ig-like domains，five potential N-glycosylation sites，a 22 amino acid transmembrane sequence and a 25 amino acid cytoplasmic domain.
来源： Human Cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

产品介绍 Product Introduction

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注意事项 Considerations

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3.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。