Recombinant Human ILDR2,BR

产品属性 Product Attributes

基本信息

别名： Angulin-3;C1orf32;Dbsm1;DJ782G3.1;ILDR2;immunoglobulin-like domain containing receptor 2;LISCH-Like
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： ILDR2 is a member of the B7-like family of proteins that regulate T cell activity，is also a known endoplasmic reticulum molecule that regulates lipid homeostasis.The human ILDR2 lumenal domain shares a 99% and 98% homology with the mouse and rat respectively.The human gene encoding ILDR2 is located in a region on Chr1q23–25 that has been associated with type 2 diabetes.ILDR2 plays critical roles in hepatic clearance of lipoproteins and in lipid homeostasis.ILDR2 regulates human dendritic cells (DC2 cells，a subpopulation of polarized DCs that promotes Th2 differentiation).Recent publications reported that ILDR2 displayed negative regulatory functions on human and mouse T cells in various experimental systems.Fusion protein of ILDR2 lumenal domain with an Fc fragment，displays therapeutic effects in collagen-induced arthritis (CIA)，a mouse model of rheumatoid arthritis (RA).ILDR2 represents a novel B7-like ligand that exerts negative immune modulation via interaction with a putative counterpart receptor expressed on activated T cells.
来源： Human Cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

产品介绍 Product Introduction

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