Recombinant Human TGFBR1/ALK-5,BR

产品属性 Product Attributes

基本信息

别名： AAT5;activin A receptor type II-like kinase,53kD;ACVRLK4;ALK-5;ALK-5ALK5;LDS1A;LDS2A;SKR4;tbetaR-I;TGFB1R1;TGF-beta receptor type I;TGFbetaRI;TGFBR1;TGF-bRI;TGFR-1
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Powder:＜-20℃ for long store;RT，3 weeks.Liquid:4-7℃，2-7 days;＜-20℃，3 months.

产品信息

背景说明： TGF-beta RI，also called ALK-5，is an approximately 55 kDa type I transmembrane serine/threonine receptor kinase.In the presence of TGF-beta，TGF-beta RI forms a complex with，and is phosphorylated by，TGF-beta RII.Phosphorylated TGF-beta RI can then transiently bind and phosphorylate Smad2 and Smad3.TGF-beta functions as a tumor suppressor by inhibiting the cell cycle in the G1 phase.Administration of TGF-beta is able to protect against mammary tumor development in transgenic mouse models in vivo.Disruption of the TGF-beta/SMAD pathway has been implicated in a variety of human cancers，with the majority of colon and gastric cancers being caused by an inactivating mutation of TGF-beta RII.TGF-beta RI is likely important during development，since mice deficient for TGF-beta RI die at midgestation with severe defects in vascular development of the yolk sac and placenta，and an absence of circulating red blood cells.Furthermore，TGF-beta RI appears to be involved in proper lymphatic network development.
来源： Human Cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

产品介绍 Product Introduction

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